Fucoxanthin inhibits the proliferation of ABCC2-over expressing cisplatin-resistance ovarian cancer cells via inducing apoptosis

Background: The development of multidrug resistance (MDR) is a major barrier to achieving effective chemotherapy in cancer. Studies have shown that epithelial ovarian cancer initially responds platinum-based therapy, however, the recurrent type often resistant treatment and associated with high mortality. Fucoxanthin, natural component found marine algae, possesses various pharmacologic properties. This study evaluated cytotoxicity reversal activity fucoxanthin on resistance-associated protein 2 (MRP2)- overexpressing, cisplatin-resistant cells (A2780RCIS) their parental (A2780). Methods: Cell viability was presence different concentrations or cisplatin fucoxanthin/cisplatin combination using MTT assay. Propidium iodide staining subG1 analysis were used evaluate potential for cell cycle modification apoptosis induction lines. Results: results showed able cause similar toxicity both lines via induction. Co-treatment (3.125 100 µM) nontoxic (1 2.5 did not reverse A2780RCIS cells. Conclusion: Although modify cells, it equally inducing death A2780 indicating an MRP2 substrate.